High-precision ID-TIMS cassiterite U–Pb systematics using a low-contamination hydrothermal decomposition: implications for LA-ICP-MS and ore deposit geochronology

Cassiterite (SnO2) is the most common ore phase of Sn. Typically containing 1–100 μgg−1 of uranium and relatively low concentrations of common Pb, cassiterite has been increasingly targeted for U–Pb geochronology, principally via microbeam methods, to understand the timing and durations of granite-related magmatic–hydrothermal systems throughout geological time. However, due to the extreme resistance of cassiterite to most forms of acid digestion, there has been no published method permitting the complete, closed-system decomposition of cassiterite under conditions in which the basic necessities of measurement by isotope dilution can be met, leading to a paucity of reference and validation materials. To address this a new low blank (< 1 pg Pb) method for the complete acid decomposition of cassiterite utilising HBr in the presence of a mixed U–Pb tracer, U and Pb purification, and thermal ionisation mass spectrometry (TIMS) analyses has been developed. Decomposition rates have been experimentally evaluated under a range of conditions. A careful balance of time and temperature is required due to competing effects (e.g. HBr oxidation), yet the decomposition of 500 μm diameter fragments of cassiterite is readily achievable over periods comparable to zircon decomposition. Its acid-resistant nature can be turned into an advantage by leaching common Pb-bearing phases (e.g. sulfides, silicates) without disturbing the U–Pb systematics of the cassiterite lattice. The archetypal Sn–W greisen deposit of Cligga Head, SW England, is used to define accuracy relative to chemical abrasion–isotope dilution–thermal ionisation mass spectrometry (CA-ID-TIMS) zircon U–Pb ages and demonstrates the potential of this new method for resolving highresolution timescales (< 0.1 %) of magmatic–hydrothermal systems. However, data also indicate that the isotopic composition of initial common Pb varies significantly, both between crystals and within a single crystal. This is attributed to significant fluid–rock interactions and the highly F-rich acidic nature of the hydrothermal system. At microbeam precision levels, this issue is largely unresolvable and can result in significant inaccuracy in interpreted ages. The ID-TIMS U–Pb method described herein can, for the first time, be used to properly characterise suitable reference materials for microbeam cassiterite U–Pb analyses, thus improving the accuracy of the U–Pb cassiterite chronometer as a whole.


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S. Tapster and J. W. G. Bright: ID-TIMS cassiterite U-P and Jones, 1992). Research into cassiterite U-Pb geochronology paused for some time due to the questionable accuracy of the first published results (McNaughton et al., 1993) and the difficulty in the hydrothermal decomposition of cassiterite required for isotope dilution methods due to the extremely acid-resistant nature of cassiterite (Gulson and Jones, 1992;Neymark et al., 2018). With the advent of microbeam techniques, cassiterite U-Pb geochronology has now become widely accessible. Techniques such as laser ablation inductively coupled mass spectrometry (LA-ICP-MS) and ion microprobe (Carr et al., 2017) offer a rapid solution to analysing the U-Pb systematics of cassiterite without the direct need for dissolving a sample. With analytical precision of ∼ 1 %-2 % 2σ and a current total uncertainty limit of ∼ 2 % based upon long-term reproducibility and inter-laboratory comparison of zircon U-Pb analyses (Horstwood et al., 2016), LA-ICP-MS U-Pb techniques offer the capability to provide chronology that may address issues such as the timing of ore deposition at broad, regional scales. Issues specific to cassiterite LA-ICP-MS U-Pb analyses are outlined below. Higher-temporal-resolution questions, such as those that begin to address processes on magmatic timescales, require a refinement of these uncertainties. For microbeam techniques this may result from the refined standardisation of the methodology and identification of systematic uncertainties identified over long-term analysis using well-characterised reference materials (RMs) (Horstwood et al., 2016).
The accuracy of U-Pb microbeam geochronology requires that effects such as matrix interaction with analyte ion beams and "down-hole" inter-element fractionation be corrected for. This is commonly negated by using RMs with an equivalent chemistry and ablation (or sputtering) characteristics (i.e. a matrix-matched RM). Samples of unknown isotopic composition are measured relative to well-characterised RMs that are relatively homogenous at the scale of the spatial resolution and at the precision of the analyses typically characterised by ID-TIMS U-Pb analyses.
Thus far, a fundamental issue for cassiterite U-Pb geochronology has arisen from the challenges of achieving the total decomposition of cassiterite in a single closedsystem step, which is required for the effective quantitative U / Pb determination of the material by isotope dilution methods. Previous ID-TIMS U-Pb studies (Gulson and Jones, 1992;Rizvanova et al., 2017;Yuan et al., 2008) utilising concentrated HCl required stepwise decomposition and acid recharges that still only achieved partial decompositions in many instances. These studies also required the postdecomposition addition of isotopic U-Pb tracers. This approach will likely preserve the Pb isotope systematics of the sample; for cassiterite this will represent a mixture of common Pb (Pbc) components and radiogenic Pb (Pb * ). However, it introduces a high potential to fractionate the U-Pb inter-element ratios, either due to the incongruous dissolution of U and Pb, and different elemental behaviours before equilibrium with the tracer is achieved. These issues will in turn affect the integrity of U-Pb-derived dates and therefore the interpretation of Pb loss or Pbc-Pb * mixing trajectories that require assumptions about concordance of the U-Pb chronometers. As noted by Neymark et al. (2018) these effects lead to reverse discordance (U loss or Pb gain) between the resulting cassiterite analyses. Whilst this effect can be easily detected in older cassiterite data wherein trajectories approach being perpendicular to concordia, within younger samples, fractionation will merely drive samples nearly parallel to the line of concordia, making it difficult to distinguish from real age variations.
Many previous microbeam cassiterite U-Pb studies have used some combination of zircon RM or glass RM, with a "matrix-matched" cassiterite RM that has had isotopic ratios characterised by ID-TIMS following a stepwise decomposition (e.g. Yuan et al., 2011Yuan et al., , 2008Zhang et al., 2017;Li et al., 2016;Liu et al., 2007). The reference values have the potential to have been effected by the issues described above, with inaccuracies propagating into the resulting in situ ages. Neymark et al. (2018) developed an approach that utilised the highly repeatable ablation characteristics of cassiterites to overcome the matrix-matching issues in microbeam analysis that stem from the absence of well-characterised cassiterite material that can be used as an RM. to The matrix biases relative to a NIST glass primary RM were normalised by deriving a "fractionation factor" for each analytical session. This was achieved by measuring the offset between the lower intercept age on a Tera-Wasserburg (T-W) plot and an assumed "true" age defined by the Pb-Pb isochron that was shown to be in good agreement with independent chronological constraints for the Proterozoic "SPG" cassiterite. The application of this approach to a wide range of materials across geological time, and the general agreement with independent geological and temporal constraints of their associated systems (Moscati and Neymark, 2019;Neymark et al., 2018), indicates that this approach was versatile and can be reliably applied to constrain the general timing of ore deposits. However, without characterising the U-Pb systematics of cassiterite materials by precise methods the potential level of accuracy in resulting geological interpretations is difficult to assess.
Regardless of the microbeam approach adopted, it is crucial that the session and long-term accuracy and dispersion of any U-Pb analytical approach can also be validated by the analysis of independently well-characterised cassiterites (i.e. secondary and tertiary RMs) (e.g. Horstwood et al., 2016). The motivation for developing a method for cassiterite ID-TIMS U-Pb geochronology that involves the total decomposition of cassiterite in the presence of, and achieving equilibrium with, a U-Pb isotope tracer is to provide a means to characterise cassiterite materials to assess accuracy and a means to examine magmatic-hydrothermal timescales within cassiterite-bearing deposits beyond the consensus ca. 2 % absolute uncertainty that is permitted by microbeam U-Pb methods (e.g. Horstwood, 2016).
Desirable characteristics of a method are also the following: (1) contribution of low amounts of Pbc to the sample during decomposition and chemical separation using reagents that can be easily handled and distilled; (2) the method can achieve decomposition on timescales that are easily operable for the laboratory environment, e.g. zircon decomposition is typically achieved within ∼ 72 h; and (3) the method utilises geologically meaningful amounts of material capable of resolving spatial variations in isotopic ratios. This study demonstrates the potential of cassiterite decomposition with concentrated HBr to fulfil the necessary criteria for routine ID-TIMS cassiterite U-Pb geochronology. We provide preliminary data for two cassiterite materials that have the potential for use as RMs, and we evaluate the accuracy of cassiterite U-Pb geochronology using the case study of the classic W-Sn magmatic hydrothermal system of Cligga Head, SW England, which illustrates the complexities and biases that may arise for cassiterite U-Pb geochronology.
Cassiterite is notoriously resistant to decomposition in acids (Mathur et al., 2017;Yamazaki et al., 2013). Although analysis of Sn isotopes within cassiterite is well-established, decomposition has typically been conducted by alkali fusion (Hall, 1980;Sear, 1997), reduction with graphite (Clayton et al., 2002;Hall, 1980) or potassium cyanide reduction (Haustein et al., 2010;Mathur et al., 2017). These methods require high temperatures (800-1200 • C) and open systems, making them inappropriate for ID U-Pb geochronology. Hydroiodic acid has been demonstrated as an effective means of cassiterite decomposition at relatively low temperatures 100 • C (Caley, 1932). More recent work was able to dissolve 1 mg of cassiterite in high-pressure decomposition vessels at 100 • C over four sequences of 24 h, exchanging the acid at each step (Yamazki et al., 2013;Mathur et al., 2017). Despite the potential of HI as a means to decompose cassiterite, there are several drawbacks as HI readily reacts with oxygen within air requiring refrigerated storage, is less readily available with certification to < 1 pg mL −1 of Pb, and is significantly more expensive when compared with HBr. Similarly, the decomposition procedure of Yamazki et al. (2013) yielded a 1 ng Sn blank, and whilst it is conjecture to predict the associated Pbc blank, if on this order of magnitude it would rule out HI as a low-contamination method for high-precision geochronology of cassiterite. Upon drying of the dissolved samples Yamazki et al. (2013) noted the formation of precipitates which were insoluble with a range of acids (HCl, HF, HClO 3 , HNO 3 ); it is possible that these could also sequester Pb and U, significantly decreasing recoveries. Previous efforts to analyse cassiterite U-Pb through ID methods for geochronology have utilised a concentrated HCl-based decomposition within high-pressure acid digestion vessels (Gulson and Jones, 1992;Liu et al., 2007;Yuan et al., 2008Yuan et al., , 2011Rizvanova et al., 2017). The previously reported contributions of Pbc from the method have been on the order of 0.2-0.3 ng (Gulson and Jones, 1992) to 0.8 ng (Yuan et al., 2011(Yuan et al., , 2008, many orders of magnitude greater than what is typically achieved by modern zircon chemical abrasion-isotope dilution-thermal ionisation mass spectrometry (CA-ID-TIMS) geochronology methods (< 0.5 pg). The issues of incomplete decomposition in previous studies was highlighted by Neymark et al. (2018). Although not explicit about the number of fractions that did not dissolve, the methods of Yuan et al. (2008) indicated that at least some of their cassiterite was not decomposed after 72 h in 12 M HCl at 205 • C in high-pressure digestion vessels and required multiple acid exchange steps as well as also further crushing with a pestle and mortar between decomposition steps. Gulson and Jones (1992) also utilised a 48-72 h, ∼ 200 • C, 12 M HCl decomposition stage within a high-pressure digestion vessel and noted that in some instances for ∼ 200 Ma cassiterite, < 5 % of cassiterite was dissolved after numerous steps. The potential for inaccuracy in cassiterite U-Pb geochronology was illustrated by Gulson and Jones (1992), who presented a very precise age (± ∼ 0.1 % 2σ ) from a discordia regression line with an upper intercept age of 2098.6 Ma ± 3.1 Ma for cassiterite associated with granitic rocks within the Bushveld Complex, South Africa. This cassiterite age was quickly challenged at the time on account of the much younger zircon ages of the associated granites (McNaughton et al., 1993). Extensive high-precision CA-ID-TIMS zircon U-Pb geochronology of the relatively older Rustenberg layered igneous suite of the Bushveld Complex (Mungall et al., 2016;Scoates and Friedman, 2008;Scoates and Wall, 2015;Zeh et al., 2015) has now confidently demonstrated that the cassiterite age is at least > 40 Myr (> 2 %) too old. The potential to decompose tin oxides at pressure using 9 M (48 %) HBr in high-pressure digestion vessels has been identified for some time now (Doležal et al., 1969), yet its application has been somewhat overlooked for U-Pb geochronology despite its strong acidic, reducing nature that is comparable to HI.

Controls on the timescales of cassiterite hydrothermal decomposition with 9 M HBr
The ability of 9 M HBr to decompose cassiterite over a range of temperatures and grain sizes was investigated in a series of step-leaching experiments. Timescales were assessed for two different cassiterite crystal samples ( Fig. 1): (1) "Casnig" with an age of ∼ 150 Ma and a heavily quenched cathodoluminescence (CL) response, indicating a high concentration of Fe (Farmer et al., 1991); (2) a single ∼ 1 cm diameter cassiterite from the Permian Cligga Head, SW England, which demonstrates strong zonation under CL. Around 0.015 to 0.03 g of cassiterite fragments, both powdered in a pestle and mortar to < 10 to 50 µm and as coarse 500 µm length cubes, was decomposed in a 50× molar excess of 9 M HBr in Savillex high-pressure digestion vessels (Parr Bombs) at a range of temperatures (180-230 • C). Decomposition steps lasted for 12 h or 96 h, and the mass decrease in the residual cassiterite was documented (see the Supplement for full data), following extraction and extensive rinsing of the leachate. The acid was recharged and the experiment repeated. Complexity in the weighing arose from Br 2 released during the decomposition steps, diffusing into the perfluoroalkoxy alkane (PFA) vessels and thus increasing the mass. The mass would then decrease as Br 2 diffused out of the PFA vessel during hotplate dry-down steps (120 • C) before weighing. Experimental runs of PFA vessels without cassiterite present indicated the potential mass variation at each weighing stage to be ± 0.00154 g (2s). Scanning electron microscope imagery and energy-dispersive spectroscopy of the precipitated leachate after a decomposition step identified crystalline tin bromide salts and spongy-textured Ti, Nb and Fe bromides which reflect minor elements contained within the cassiterite (Fig. 1). No tin oxide was identified, supporting the idea that the mass reduction at each stage was due to the decomposition of cassiterite in HBr. Decomposition experiments run at 180 and 200 • C did not exhibit a significant reduction in mass beyond the mass variation in the beaker due to Br 2 diffusion. No clear temperature control was exerted between 210 and 230 • C, and most experiments demonstrated a relatively large variation in the amount dissolved over 12 h from step to step. Likewise, there was no consistent variation in the amount decomposed over 12 h between the two different starting materials of cassiterite at a given temperature. In general more cassiterite decomposed when powdered in a pestle and mortar than when placed in as larger fragments, although significant variation in the rate of a given step was still present. Notably there was little variation between the total mass of cassiterite decomposed in either a 96 h step or a 12 h step, indicating the majority of cassiterite decomposition occurs within the first 12 h or less. We suggest that this apparent decrease in rate resulted from a rapid reduction in HBr molarity when HBr was exposed to high temperatures. The strong brown discolouration and mass increase of the decomposition vessel, which was not unique to cassiterite-bearing experiments, implied that Br 2 was likely generated through a reaction with atmospheric oxygen. It is well-documented that aqueous solutions of HI readily react with atmospheric oxygen at room temperatures to produce I 2 , which further reacts with HI to produce HI 3 , and a similar reaction between O 2 and HCl occurs, just at a much slower rate (and requiring higher temperatures). It follows that this reaction occurs with HBr, although it ap- pears not to be previously well-documented. The decomposition experiments act as an informative guide for cassiterite decomposition, but given the scales of the experiment design required to overcome weighing issues, it is unlikely that they comprehensively reflect the rates of cassiterite decomposition in 9 M HBr. Whether a cassiterite sample completely decomposes within a single step is likely to be fundamentally controlled by the surface area to volume (or mass) ratio of the cassiterite that is exposed to the acid during the earliest stages of decomposition, before the HBr is lost and becomes ineffective for cassiterite decomposition. Use of a significant excess of concentrated HBr is proposed; in the later experiments for U-Pb geochronology a molar excess of ∼ 190 times was used. To ensure that complete singlestep decomposition can be achieved, we advise carrying out a trial decomposition experiment to ensure that a given mass and fragment size of a specific cassiterite sample can be decomposed within the parameters of the experiment chosen.

Method for cassiterite ID-TIMS U-Pb geochronology
An overview of the methods employed and described within this section is provided in Fig. 3, in addition to petrogenetic characterisation techniques that can be employed within the workflow prior to ID-TIMS U-Pb analyses, although these have not been fully utilised within this study. The specifics of sampling style, sizes and experimental conditions are offered as guidelines. Their selection will be dependent on user requirements and the nature of the sample material.

Sample preparation
Fragments of cassiterite grains were crushed under acetone in a pre-cleaned agate pestle and mortar and transferred to a PFA beaker. The acetone was then evaporated and the powdered material was rinsed first in H 2 O, then with 4 M HNO 3 before being refluxed in aqua regia at 120 • C overnight with the aim of dissolving sulfide and Fe oxide inclusions that were exposed within the powdered cassiterite grains (e.g. Gulson and Jones, 1992). Samples were rinsed in 4 M HNO 3 and H 2 O. In the case of samples that underwent an additional step of HF leaching, samples were refluxed at 120 • C overnight in ∼ 300-400 µL 29 M HF and trace HNO 3 on a hotplate. The leached cassiterite was then rinsed in 4 M HNO 3 and H 2 O. Sub-aliquots of leached cassiterite material that visually approximated the material contained in a ∼ 500 µm sided cube of cassiterite were then transferred into 500 µL PFA microcapsules (Parrish, 1987) that had undergone several steps of overnight cleaning in 9 M HBr within the Parr vessels, in addition to normal HF and HCl cleaning routines. Samples were briefly (∼ 30 min) refluxed (hotplate, 120 • C) and rinsed in 1 M HBr, leaving a minimal amount of acid in the capsule, whilst at the same time ensuring no sample material was removed before being spiked with ∼ 0.005 g of EARTHTIME 535 tracer (Condon et al., 2015). Approximately 450 µL of 9 M HBr (Romil ultra-purity acid -UPAanalysed to have < 0.04 pg mL −1 of Pbc) was added before placing in the oven for five nights at 210 • C within a highpressure digestion vessel. Following decomposition, the solution was dried on a hotplate at 120 • C and converted to a chloride by the addition of 400 µL of 3 M HCl and placed in the oven for a further 12 h at 180 • C using a high-pressure vessel. One noteworthy observation made over the course of cleaning the PFA capsules in 9M HBr overnight at 230 • C was that the apparent Pbc was found to have doubled relative to the previous cleaning stage at 210 • C, and the equivalent amount of in-house 208 Pb tracer produced very poor beam intensities. This was interpreted as a result of organic compounds released by the reaction of the HBr with the PFA capsule. Despite potential benefits from more rapid decomposition at 230 • C, lower temperatures are recommended. Figure 3. A generalised workflow for cassiterite ID-TIMS U-Pb geochronology. ID-TIMS analyses can be employed after the listed petrogenetic characterisation techniques on sample material. The schematic representation of sample aliquots and sub-aliquots illustrates the different approaches utilised within the study based on application (characterising heterogeneity in reference materials or internal isochron approach to avoid issues with spatial heterogeneity in Pbc composition; see Fig. 7 for further details on internal isochron formed from subaliquots). Note that many experimental variables will be sample material and user requirement dependent. For a discussion of decomposition times, see Sect. 4.

Cassiterite U-Pb anion exchange chromatography
A two-stage column chemistry procedure was determined following investigations to isolate Pb and U from matrix elements using 0.05 mL of pre-cleaned AG 1-x8 200-400 mesh resin (BIO-RAD, CA, USA) and a homogeneous solution of dissolved cassiterite equating to a ∼ 500 µm length cube grain (or 0.875 mg at an assumed density of ∼ 7 g cm −3 ). In the first stage a modification of the HCl-based anion exchange chromatography typically used for zircons (Krogh, 1973) was used. The sample was loaded onto the columns in 3 M HCl, before further 3 M HCl being added in several stages of 30 µL and then several stages of 130 µL 3 M HCl. These washes contained the majority of eluted Nb, Ti and Th. The Pb was eluted in three stages of 150 µL 6 M HCl, collected and dried down with ∼ 10 µL 0.03 M H 3 PO 4 . The U was eluted using three steps of 150 µL of H 2 O, followed by one step of 150 µL of 1 M HCl. As the U fraction was found to contain almost all eluted Fe and Sn, a further U clean-up stage was required. The U-bearing solution was dried and re-dissolved in 300 µL 8 M HNO 3 before being loaded onto columns, again containing 0.05 mL of pre-cleaned AG 1-x8 resin. Columns were washed in three stages of 350 µL 8 M HNO 3 , followed by two steps of 350 µL 8 M HCl. The U was eluted using two steps of 200 µL 0.2 M HCl, collected and dried down with ∼ 10 µL 0.03 M H 3 PO 4 .
For steps after crushing in a pestle and mortar, the Pbc procedural blank was found to be on the order of ∼ 0.5 pg. The procedural blank will be subject to laboratory variations, and the efficacy with which any material abraded during crushing within a pestle and mortar can be removed prior to decomposition within HBr. The effects of HF leaching prior to decomposition are evaluated below; the lowest total sample and laboratory Pbc of ∼ 1.5 pg, including any pestle and mortar contributions, indicates that crushing is a minor contributor to post-HF leaching. Crucially, the component of Pbc contributed by the method is 1 to 4 orders of magnitude less than the amount of Pb * of the materials examined within this study, and the initial Pbc within the cassiterite is likely 1 or 2 orders of magnitude greater than that from the laboratory.

Mass spectrometry and data reduction
The Pb and U of a given sample were independently loaded on a zone-refined Re filament in 1.5 µL of silica gel ma-trix (Gerstenberger and Haase, 1997). Isotope ratio measurements were made using a Thermo Triton TIMS at the British Geological Survey following typical methods described by Tapster et al. (2016). Raw U and Pb data were filtered using the Tripoli software programme (Bowring et al., 2011). Data reduction and uncertainty propagation used a modified Excel spreadsheet (Schmitz and Schoene, 2007) with the U decay constants of Jaffey et al. (1971), the 238 U / 235 U ratio of Hiess et al. (2012) and the decay constants of Cheng et al. (2000) for 230 Th. Concordia diagrams and regressions were constructed using the Excel add-in ISOPLOT 4.15 (Ludwig, 2008), and initial disequilibrium corrections utilised the IsoplotR package (Vermeesch, 2018) 4 Cassiterite ID-TIMS U-Pb results

SPG-IV ad hoc RM cassiterite
The SPG-IV cassiterite is taken from the Pitkäranta ore district, Russian Karelia, and was utilised by Neymark et al. (2018) as a cassiterite reference material for deriving the fractionation factor of analytical sessions. The age of the cassiterite based on geological constraints and zircon dating of associated magmatism was inferred to be between 1546.7 and 1537.9 Ma (Amelin et al., 1997). Neymark et al. (2018) presented an LA-ICP-MS 207 Pb * / 206 Pb * weighted-mean date of 1542.7 ± 1.5 Ma and a date of 1539.8 ± 3.5 Ma for three partially dissolved, reversely discordant ID-TIMS analyses (N. Rizvanova, written communication, 2017, in Neymark et al., 2018. The free regression of three tightly clustered ID-TIMS analyses (Fig. 4) of spatially independent aliquots of the SPG-IV cassiterite yields a lower intercept of 1535.9 ± 5.5 Ma (mean squared weighted deviation or MSWD = 2.0). As utilised by Neymark et al. (2018) for dates that cluster close to concordia, anchoring the common Pb component of the T-W isochron to the mean 207 Pb / 206 Pb value of 11 galena analyses from the ore system (1.0104±0.0062) (Larin et al., 1990) generates a lower intercept date of 1536.6 ± 1.0 (MSWD = 1.02) (Fig. 4). The total Pbc amounts for these analyses range from ∼ 5 to 15 pg, and 206 Pb / 204 Pb ranges from ∼ 12 000 to ∼ 23 000.
Comparison of the ID-TIMS T-W lower intercept dates with the LA-ICP-MS Pb-Pb isochron dates used to derive the fractionation factor (Neymark et al., 2018) indicates an absolute offset ∼ 0.4 % older for the LA-ICP-MS Pb-Pb isochron data. The equivalent ID-TIMS 204 Pb / 206 Pb-207 Pb / 206 Pb isochron date for this study yields 1540.9 ± 3.6 Ma, which is broadly in concert with that derived by the LA-ICP-MS data (Neymark et al., 2018).

Jian-1 cassiterite
The Jian-1 cassiterite is derived from the Jiangxi W-Sn district, South China (Neymark et al., 2018). Previously, Four individual aliquots of the Jian-1 cassiterite were analysed by ID-TIMS. All data are discordant on the T-W plot (Fig. 5) and are interpreted as containing a component of initial common Pb. The total Pbc amounts for these analyses range from ∼ 1.5 to 14 pg, and their 206 Pb / 204 Pb ranges from ∼ 140 to ∼ 5300. The three data points with the greatest 206 Pb / 204 Pb form a lower intercept of 155.05 ± 0.20 Ma (MSWD = 2.1), in agreement with the lower intercept formed by all four data points of 154.969 ± 0.082 Ma (MSWD = 1.4).
Comparison with LA-ICP-MS data (Fig. 5) indicates that the coarser-scale sampling of ID-TIMS analyses identified domains with lower Pb * / Pbc relative to the previously published LA-ICP-MS data (Neymark et al., 2018) and therefore provides additional spread and an isochron on the T-W plot that seemingly was not permitted by the LA-ICP-MS data. Despite this, the isochron overlaps within uncertainty with the majority of previously published LA-ICP-MS data for Jian-1 (Neymark et al., 2018), indicating that the accuracy of the measurements by microbeam was relatively robust at the 1 %-3 % precision of single data points. However, the ID-TIMS lower intercept date of 154.969 ± 0.082 Ma is ∼ 1 % younger than the LA-ICP-MS weighted-mean 206 Pb / 238 U date of 156.55 ± 0.36 Ma (n = 40; MSWD = 1.4) (Neymark et al., 2018). This offset would likely be reduced further if a fractionation factor was renormalised to the ∼ 0.4 % younger ID-TIMS intercept date of SPG-IV than was assumed by Neymark et al. (2018). However, this would still not fully account for the offset on the weighted mean at the ±0.23 % 2σ precision stated for Jian-1 (Neymark et al., 2018).

Evaluating the accuracy of cassiterite U-Pb
dating: the geochronology of Cligga Head, SW England

Geology and previous geochronology of Cligga Head W-Sn deposit
The Cligga Head W-Sn greisen deposit is located at the central-northern periphery of the post-Variscan, early Permian, SW England Cornubian Batholith, UK. Key features of the local geology ( Fig. 6; Hall, 1971;Jackson et al., 1977;Moore and Jackson, 1977) are a porphyritic granite stock that intruded and locally thermally metamorphosed Devonian pelitic and psammitic meta-sediments at the contacts at about 1 kbar (Hall, 1971). The westerly extent of the granite has been eroded by the coastline. The main granite stock is cross-cut by a complex of sheeted quartz-muscovite (< 1 % topaz and fluorite) greisen-bordered veins that predominantly contain quartz, in addition to tourmaline, chlorite, fluorite, cassiterite-stannite-arsenopyrite, wolframite and minor Cu sulfides. The cassiterite-bearing greisen-bordered veins extend across the contact into the meta-sediments. Rhyolite porphyry dykes intruded ∼ 150 m south of the stock. The absence of W-Sn mineralisation and greisenisation of the dykes, in addition to reported xenoliths of the granite greisen within the dykes (Reid et al., 1906), indicates that they occurred after the W-Sn mineralisation, although they contain disseminated chalcopyrite and supergene derivatives . Previous geochronology of muscovite from the greisened zones indicated a date of ∼ 280 Ma for the magmatic-hydrothermal system (Fig. 6). Two LA-ICP-MS U-Pb ages were presented (Moscati and Neymark, 2019) for cassiterite from Cligga Head: a TW lower intercept age of 287.9 ± 2.6 Ma (n = 59; MSWD = 2.2; initial 207 Pb / 206 Pb value of 0.790 ± 0.034) or an anchored isochron with a lower intercept of 289.

Samples and zircon CA-ID-TIMS U-Pb geochronology methods
Samples of the granite porphyry stock and the rhyolite porphyry dyke (Fig. 6) were analysed by zircon CA-ID-TIMS U-Pb in order to provide constraints on the timing of cassiterite mineralisation. Zircon was analysed with the ET535 tracer, and methods followed Tapster et al. (2016) using the same decay constants and 238 U / 235 U as the cassiterite analyses. Data are corrected for initial 230 Th disequilibrium using a Th / U (melt) of 1.43 derived from a mean of granitic magmatism in the Cornubian Batholith (Simons et al., 2016). All data are contained within the Supplement.

5.3
Zircon CA-ID-TIMS U-Pb results and the "age window" for Cligga Head cassiterite The 10 analyses of zircon tip fragments from the host granite stock yield a range in 206 Pb / 238 U CA-ID-TIMS dates of ∼ 290 to ∼ 285 Ma. The youngest four dates form a statistically acceptable weighted mean of 285.163 ± 0.097 Ma (MSWD = 1.01; n = 4), which is interpreted as the emplacement age (Fig. 6).
The eight analyses of zircon tip fragments from the porphyritic dyke, which intrudes to the SE of the stock, yield 206 Pb / 238 U dates of ∼ 290 to ∼ 282 Ma. The youngest date, whilst overlapping with concordia within its relatively low single data-point uncertainty, demonstrates high discordancy (∼ 11 %) and does not form a single population weighted mean with any other dates; it is therefore attributed to residual Pb loss and rejected from the age interpretation. The youngest dates that form a statistically acceptable weighted-mean date yield an age of 283.21 ± 0.032 Ma (MSWD = 0.01; n = 3) taken as the timing of emplacement (Fig. 6).
The dates for magmatic events at Cligga Head provide the minimum and maximum constraints on the absolute timing of the magmatic-hydrothermal greisen system and the true "age" of cassiterite that is independent of the cassiterite isotopic dates. They define a possible window for the "true" age of cassiterite of 1.95 ± 0.33 Myr, or about 0.7 % of the ∼ 285 Ma absolute age.

Cligga Head cassiterite ID-TIMS U-Pb geochronology
Cassiterite was sampled from two locations at Cligga Head (Fig. 6). From the first locality within the granite stock a single crystal (C1) was used within the decomposition experiments. In the first experiment a single part of the crystal was powdered into a single "parental" aliquot and divided into eight approximately equal parts. We evaluated the effect of not leaching four of these cassiterite fractions in 29 M HF relative to leaching, as described above and used in all of the other experiments (Fig. 7). We then evaluated intracrystal variation in U-Pb systematics by analysing an additional three, spatially independent, parts of the same C1 crystal. To evaluate the inter-sample variation, fragments from four independent crystals were analysed from a second vein (C2) containing multiple cassiterite crystals that was sampled   Moore and Jackson, 1977) with the localities of zircon samples (Z1 and Z2) and cassiterite samples (C1 and C2) marked; pale blue signifies sea level. (b) Zircon CA-ID-TIMS U-Pb dates and weighted-mean ages for Cligga Head magmatism of the porphyritic granite stock (Z1) and rhyolite porphyry dykes. Dark shaded boxes represent single analyses of zircon tips, and pale boxes represent weighted-mean dates. The intrusions define a period of ∼ 0.7 % of the absolute age in which the cassiterite may have formed. Uncertainties are presented as ±x/y/z, where x represents analytical uncertainties only for comparison with cassiterite ID-TIMS U-Pb dates also using the ET535 tracer; y represents analytical and tracer calibration uncertainties; and z is the total uncertainty including the 238 U decay constant for comparison with ages derived from other decay systems. (c) Comparison of zircon CA-ID-TIMS U-Pb weighted-mean dates with previous geochronology for the greisen system (Chen et al., 1993;Halliday, 1980). from within the meta-sediments. Cassiterite ID-TIMS methods followed those described above (Sect. 5). All cassiterite U-Pb data are contained within the Supplement.

Comparison of HF-leached and non-HF-leached cassiterite from the same parental sample
The sub-aliquots from the same parental powdered fragment of crystal (C1.1) that did not undergo HF leaching ranged from ∼ 36 to ∼ 55 pg of Pbc ( 206 Pb / 204 Pb = 108 to 207), and one aliquot yielded 7 ng of Pbc. Their regression line on the T-W plot forms a lower intercept of 283.0 ± 3.9 Ma with a statistically unacceptable MSWD of 36. The four sub-aliquots that were HF-leached contained 6.7 to 47 pg of Pbc ( 206 Pb / 204 Pb = 97.7 to 691) and yielded a lower intercept age of 285.14 ± 0.25 Ma with a statistically acceptable MSWD of 0.55 (n = 4) and a y intercept of 0.8760±0.0058. None of the non-HF-treated analyses form a single population (statistically acceptable MSWD) when combined with the regression line generated by the four HF treated subaliquots.

Intra-grain cassiterite U-Pb variability
The three spatially independent aliquots from the same crystal (C1.2-C1.4) did not yield a statistically acceptable MSWD on their regression (lower intercept age = 284 ± 20 Ma; MSWD = 7.2; n = 3). Only one of the three spatially distinct fragments of the same crystal fractions forms a single population with the HF-leached C1.1 regression line, forming a lower intercept age of 285.19 ± 0.22 Ma (n = 5; MSWD = 0.73). All HF-leached aliquots from the same crystal (C1) form a lower intercept age of 285.67 ± 0.72 Ma with a statistically unacceptable MSWD of 10.1 (n = 7). The total Pbc amounts for these analyses range from ∼ 3 to 8 pg, and their 206 Pb / 204 Pb ranges from ∼ 400 to ∼ 620. Anchoring the lower intercept to the previously determined ∼ 285 Ma lower intercept date of C1.1, and thus estimating the minimum possible 207 Pb / 206 Pb intercept value due to the constraints offered by the granite age, yields a 207 Pb / 206 Pb intercept of 0.848, 0.807 and 0.783 (± ∼ 2 %), lower than the previously determined intercept of ∼ 0.876 for the same crystal. Figure 8. T-W plot and regression lines for HF-leached cassiterite from Cligga Head relative to possible age defined by zircon (Fig. 6). Regressions are for the following: C1.1 sub-aliquots (n = 4) as presented in Fig. 7; spatially independent samples of the same crystal (n = 3); and independent crystals from a different vein (C2) (n = 4). Note that the y intercept value is for regression anchored to the maximum possible lower intercept as defined by the granite; it therefore represents a maximum y-intercept value. Only the sub-aliquots of C1.1 yield a regression without over-dispersion. See the text for further discussion.

Inter-vein and -grain variation in U-Pb systematics
No analyses derived from individual crystals of the second hand sample (C2) form a single population when integrated with data that formed the isochron of C1.1 (Fig. 8). Neither do the four analyses form a single population between themselves, yielding a lower intercept of 286.2 ± 5.0 Ma with a statistically unacceptable MSWD = 48 (n = 4) and 207 Pb / 206 Pb intercept of 0.72 when freely regressed and 0.66 (± 5 %) when anchored to the C1.1 lower intercept date and maximum possible age derived from the granite of ∼ 285.1 Ma (Fig. 8). The total Pbc amounts for these analyses range from ∼ 4 to 17 pg, and their 206 Pb / 204 Pb ranges from ∼ 430 to ∼ 1300.
Again, to estimate the maximum initial 207 Pb / 206 Pb by anchoring the lower intercept of each date the maximum possible age intercept defined by the granite yields a y-intercept initial 207 Pb / 206 Pb for each data point of 0.695, 0.643, 0.595 and 0.561 (± 0.7 %-2.3 % 2s), significantly lower than the value derived for C1.1 (∼ 0.876).

Discussion
This cassiterite U-Pb dataset, combined with prior work (e.g. Li et al., 2016;Moscati and Neymark, 2019;Neymark et al., 2018;Zhang et al., 2017), highlights the potential for U-Pb dating of cassiterite using both microbeam and isotope dilution methods. Such datasets also reveal some complexities and issues that need to be considered when deriving meaningful ages from cassiterite dates.

Assessing U-Pb systematics of (Cligga Head) cassiterite
The range of ID-TIMS experiments described above permits us to evaluate the U-Pb systematics of cassiterite at high precision and within the context of independent geochronological constraints derived from zircon CA-ID-TIMS dating within a well-constrained geological model. There are three key features of the dataset.
1. The lower intercept date formed by a single population of HF-leached cassiterite sub-aliquots of the same parental material (C1.1) indicates a binary mixing line between an initial Pb and a radiogenic Pb source. The lower intercept yields a precise date that is consistent with the indirect age constraints on cassiterite U / Pb * . The effects of any initial isotopic disequilibrium have to be considered when deriving a sample age and uncertainty (see below).
2. The over-dispersion of non-HF-leached cassiterite compared to HF-leached C1.1 cassiterite analyses (Fig. 7) indicates non-binary mixing between initial and radiogenic Pb. The non-HF-leached experiments contained a greater contribution of Pbc, with the high MSWD indicating different sources and/or isotopic compositions of Pbc that varied in the magnitude of contribution between sub-aliquots. Both sets of experiments (Fig. 7) were treated with aqua regia prior to analysis as with previous cassiterite ID-TIMS studies (Gulson and Jones, 1992). These results therefore indicate that leaching with concentrated HF is an effective means to remove the Pbc contained within inclusions in the cassiterite that are exposed to the surface during crushing in a pestle and mortar. The results also indicate that HF leaching is effective in removing Pbc-bearing contaminants introduced by crushing a in pestle and mortar, as proposed as a potential issue by Neymark et al. (2018). The acid-resistant nature of cassiterite and ability of HF to dissolve silicate minerals without partially dissolving the cassiterite, potentially leading to the incongruous removal of Pb or U, make this an important step to remove non-lattice-bound Pbc prior to decomposition by HBr and improve the accuracy of resulting ID-TIMS U-Pb dates.
3. The differences between spatially independent samples from within and between crystals, and between cassiterites from different veins (Fig. 8), indicate localised controls on the U-Pb systematics of cassiterite. Only one spatially independent fragment from the same crystal of cassiterite forms a single population with the isochron of HF-leached C1.1 described above. A dataset 436 S. Tapster and J. W. G. Bright: ID-TIMS cassiterite U-P based upon aliquots of the same crystals (C1.2, C1.3, C1.4) yields a similar age as the C1.1 isochron but is over-dispersed and the lower intercept is less precise. A similar cassiterite U-Pb ID-TIMS dataset from a different vein (C2) is also over-dispersed and plots distinctly to the left of the C1 mixing array between the constrained crystallisation age and initial Pbc 207 Pb / 206 Pb compositions.
Open-system behaviour with respect to Pb (Pb loss) would shift data points to the right (higher U / Pb) of the C1.1 (or similar) isochron. Estimated uranium concentrations (see the cassiterite ID-TIMS U-Pb data table in the Supplement) are similar between cassiterites from the two veins and as such there is no apparent reason why uranium mobility would be manifest to a greater extent between different veins. We consider the most likely explanation to be that the overdispersion results from variation in the initial Pbc of the cassiterite to more "radiogenic" initial 207 Pb / 206 Pb values than ∼ 0.88 as defined by the C1.1 isochron, potentially as low as ∼ 0.56. The majority of documented 207 Pb / 206 Pb values from feldspars in granites and fluid inclusions in the Cornubian Batholith are ∼ 0.8-0.9 (Hampton and Taylor, 1983;Wayne et al., 1996), with only one magmatic feldspar analysis yielding a 207 Pb / 206 Pb of ∼ 0.55 (Hampton and Taylor, 1983). It is unlikely that these low values reflect the primary input signature from the magmatic volatiles. Initial Pb values with 207 Pb / 206 Pb this low are uncommon but are present in a global array of vein carbonates (Roberts et al., 2020). When the nature of cassiterite-bearing greisen systems, such as Cligga Head, is taken into account, the ability to generate atypical Pbc isotopic compositions is less surprising. Greisenisation at the margins of the cassiterite-bearing veins represents extensive, destructive, fluid-rock interaction and elemental exchange during alteration of host rocks by high temperatures of ∼ 450-300 • C and highly acidic, fluorine-rich (HF) fluids (Burt, 1981;Codeço et al., 2017;Lecumberri-Sanchez et al., 2017). As at Cligga Head, W-Sn greisen-bordered vein magmatic-hydrothermal deposits are commonly hosted by, or are proximal to, thick continentally derived sedimentary packages (Lecumberri-Sanchez et al., 2017) that likely represent the source of Sn enrichment prior to magma genesis (Romer and Kroner, 2016). These sediments will contain older U-and Pb * -rich continental mineral detritus (e.g. zircon, monazite) that can be extensively leached by the hot, F-rich, acidic ore-forming fluid, generating significant spatial and temporal variations in the Pbc isotopic composition incorporated into the cassiterite lattice over the lifetime of single crystal precipitation and the magmatic hydrothermal system as a whole. It is perhaps significant that the cassiterite that appears to contain the lowest initial Pbc component originates from a vein bordered by greisened meta-sediment rather than being hosted within the granitic stock.

Cassiterite U-Pb ages and effects of initial U-Th disequilibrium
The high-precision U-Pb lower intercept cassiterite date (C1.1; Figs. 7 and 8) comes with the caveat that it is not corrected for potential initial isotopic disequilibrium effects within the 238 U decay chain. In zircon geochronology a deficit in 206 Pb due to 230 Th disequilibrium (Schärer, 1984) can be reasonably corrected using a reasonable assumption of the mineral-melt partition coefficient or an estimate of melt Th / U, as well as an estimate of mineral Th / U, typically based on assumed 208 Pb / 232 Th-206 Pb / 238 U concordance for zircon ID-TIMS data. Cassiterite typically has extremely low 232 Th relative to U (Th / U = < 10 −4 ; Neymark et al., 2018). This geochemical feature may be derived from the preferential partitioning of U into ore fluids and/or the preferential partitioning of U upon the precipitation of cassiterite, leading to a deviation from secular equilibrium. Both processes will require a significant correction for a deficiency in 206 Pb due to low 230 Th / 238 U activity in the initial cassiterite. Alternatively, this geochemical feature could simply be explained by processes that do not preclude secular equilibrium with regards to 230 Th upon cassiterite crystallisation. These include low 232 Th / 238 U magmatic ore fluid sources or the contribution of localised U-rich components to fluids that are in secular equilibrium with regards to 230 Th and 238 U during alteration around veins. In these cases the 232 Th-208 Pb system would not provide a realistic proxy for initial 230 Th disequilibrium in cassiterite. It must also be considered that the hydrothermal fluids, and therefore the initial cassiterite, may not have been in secular equilibrium for 238 U-234 U. A relative excess of 234 U or a 234 U / 238 U activity ratio > 1 at the time of cassiterite precipitation will result in an excess of 206 Pb / 238 U, an older measured date relative to the true age. These effects therefore counteract effects of 206 Pb deficiency due to 230 Th disequilibrium. Mixing with meteoric fluids appears to be an important process in cassiterite formation (Fekete et al., 2016), and as highlighted by the compilation of Roberts et al. (2020) the 234 U / 238 U activity of crustal fluids can be in excess of 1 (shallow groundwater median value of 2.25; hydrothermal fluid median of 1.41).
Estimates of the effects of initial disequilibrium (Fig. 9) indicate that corrections for the exclusion (or absence) of initial 230 Th, potentially inferred by the characteristic low 232 Th / U in cassiterite, produces a maximum possible date (∼ 285.23 Ma) that is still within uncertainty of the maximum age permitted by the granite host. Effects of excess initial 234 U indicate that an activity ratio of 1.5 produces dates ∼ 200 kyr younger (284.92 Ma) than that of secular equilibrium, yet it also lies within the analytical uncertainties of the host granite. In the more extreme scenario of a 234 U / 238 U activity ratio of 2.5, this is reduced to 284.55 Ma and would be significantly younger. Not accounting for the uncertainty that arises from the potential effects of disequilibrium, the lower intercept of the four-point isochron C1.1 yields a precision of ± 250 kyr or 0.088 % (2σ , analytical uncertainties only) and agreement with the possible window for hydrothermal activity defined by the CA-ID-TIMS zircon dates of the intrusions (∼ 0.7 %). Moreover, it also demonstrates a clear temporal association with the granitic stock that hosts the Cligga Head deposit (the cassiterite date is 0.021 ± 0.268 Myr younger than the zircon date for the granitic stock) (Figs. 9, 10). High-precision constraints on the durations of relatively simple ore-forming magmatic-hydrothermal systems spatially associated with single intrusions indicate timeframes of tens to hundreds of thousands of years Tapster et al., 2016). It is therefore feasible that the emplacement of the host granite stock, cooling to the 400-350 • C temperature interval of cassiterite precipitation (Smith et al., 1996), and the transfer of ore-forming volatiles from depth all occurred within the timeframes defined by the < 0.1 % uncertainty of the zircon and cassiterite data presented here. However, considering the potential uncertainty due to initial U-Th disequilibrium effects over geologically reasonable assumptions, the cassiterite uncertainty could be expanded by ca. −200 kyr and would be asymmetric (Fig. 9). At present the poor understanding of isotopic disequilibrium effects due to elemental partitioning into ore fluids and cassiterite represents a limitation for the accurate interpretation of absolute ages of cassiterite beyond the <∼ 500 kyr timescale.  (Stacey and Kramers, 1975) was used. Data are shown relative to the freely regressed ID-TIMS lower intercept of C1.1 that shows excellent agreement with the host granite age. Pbc-corrected dates range from being in good agreement with the age constraints to being offset by ∼ 4 Myr relative to the maximum possible age of cassiterite defined by zircon dates for the granite. The samples analysed in a previous LA-ICP-MS study from Cligga Head (Moscati and Neymark, 2019) illustrate similar magnitudes, and the direction of offset can be observed in both the T-W regressions. Despite the agreement of the Pbc-corrected (Pbc*) weighted-mean 206 Pb / 238 U date 290 Ma (Stacey and Kramers, 1975) of one sample, this approach to data interpretation is invalid; see the text for discussion.

Implications and strategies for LA-ICP-MS U-Pb cassiterite geochronology
In this study we have generated ID-TIMS U-Pb data on cassiterite that has undergone full decomposition in a single stage. These include samples that have previously been used for LA-ICP-MS studies using an approach to U / Pb normalisation using an ad hoc cassiterite reference material with an inferred U / Pb age. The comparison of the ID-TIMS and LA-ICP-MS U-Pb data provides a direct means to assess the accuracy of the microbeam dates (Moscati and Neymark, 2019;Neymark et al., 2018), which show agreement at the ca. 1 % level and are therefore comparable to the quoted levels of accuracy and similar to the accuracy for U-Pb (zircon) studies (Horstwood et al., 2016). Additional characterisation over a wider range of cassiterite materials by the ID-TIMS methods described here will establish a focal point for the refinement of cassiterite measurement uncertainties by LA-ICP-MS.

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S. Tapster and J. W. G. Bright: ID-TIMS cassiterite U-P The ID-TIMS U-Pb data from the Cligga Head cassiterite strongly suggest that the initial Pb isotopic composition varies and that a simple binary mixture between a radiogenic and initial Pb may not be expected within and between crystals. A high proportion of LA-ICP-MS U-Pb cassiterite datasets record over-dispersion (e.g. ∼ 2/3 of samples, typically analysed from single crystals; reported by Neymark et al., 2018), suggesting that these are also not strict binary mixtures. We postulate that some of the over-dispersion can be attributed to variable initial Pb isotopic compositions within cassiterite that are inherited from the hydrothermal systems. This complexity in the U-Pb systematics represents a potential limitation on the accuracy of the resulting age interpretation of cassiterite. This limitation is interdependent with the single data-point precision of the U-Pb analyses and the ability to resolve different populations of the Pbc mixing endmember that will bias the regression of a dataset away from the accurate lower intercept.
We explore how the U-Pb data can be leveraged with variable Pbc by correcting the Cligga Head dataset using a widely employed strategy for minerals that accommodates Pb into their lattice upon formation, which involves correcting the component of initial Pbc using a model Pbc value at ∼ 285 Ma (Stacey and Kramers, 1975). Figure 10 demonstrates that the resulting Pbc-corrected 206 Pb / 238 U dates range from being in good agreement with the host granite age to being "too old" by ca. 4 Myr (∼ 1.5 %). Without the maximum constraint from the age of the granite, these "model" U-Pb cassiterite dates alone could be misinterpreted as a protracted episode of mineralisation. Comparable shifts, both in magnitude and direction, can be observed (Fig. 10) within one of the two samples from the same deposit that were analysed by LA-ICP-MS U-Pb (Moscati and Neymark, 2019). Figure 11 illustrates how the ability to resolve this effect and the interplay with lower precision on single data points can impact the accuracy of the regression and age interpretation. The isochron we construct is based upon all Cligga Head cassiterite ID-TIMS U-Pb analyses but with uncertainties expanded to ±1 % (2σ ) (Fig. 11). It shows no dispersion (MSWD = 1.2, n = 12); however, the resulting age is biased too old (lower intercept at 286.80 ± 0.95 Ma) for the known maximum possible age that is defined by the granite.
The approach of taking weighted means of common Pbcorrected 206 Pb / 238 U data is strongly advised against, as it diminishes the evaluation of dispersion within the data and ignores the uncertainty of 207 Pb / 206 Pb measurements (see Horstwood et al., 2015, for community discussion of this issue in LA-ICP-MS U-Pb). However, to demonstrate that this approach does not resolve the issues of variable initial Pbc composition, the weighted-mean date of Pbc-corrected 206 Pb / 238 U dates for the same dataset with uncertainties expanded to 1 % is 286.23 ± 0.83 Ma (MSWD = 1.3; n = 12; therefore, despite its seemingly precise date, it also lies outside the uncertainty of the maximum possible age defined by the granite. Figure 11. Illustration of how variable Pbc compositions in cassiterite form a "single population", yet with an inaccurate T-W lower intercept within lower single data-point precision datasets. The data are all HF-leached ID-TIMS U-Pb data from Cligga Head with artificially expanded single data-point uncertainties of 1 % (2s) for both 238 U / 206 Pb and 207 Pb / 206 Pb. This level of uncertainty is therefore a reasonable illustration of the upper range of analytical precision that may be achieved through microbeam techniques in relatively low-U-concentration materials such as cassiterite. Note that the data with artificial uncertainties do not show excess dispersion (statistically acceptable MSWD) but produce a relatively precise lower intercept (0.33 %) outside the uncertainty and older than the maximum permitted age of cassiterite delineated by the granite (Fig. 6). This does not factor in any additional systematic or analytical inaccuracy from lower-precision methods.
Any bias resulting from Pbc variation would be in addition to greater scatter on individual data points resulting from lower-precision measurements. This reinforces the limitations on the accuracy of the interpreted ages when derived from high-n but lower-precision datasets due to heterogeneity being masked by the single data-point uncertainty. In addition to the limits of systematic uncertainties defined by validation RMs, this limitation should be taken into account within future microbeam work with cassiterite, alongside any mineral phase that contains initial Pbc.
We note that the reference values of any cassiterite material used as an RM should not be corrected for Pbc or any initial isotopic disequilibrium effects; rather, they should reflect the isotopic values of the material ablated (Horstwood et al., 2016), as with the data presented in Figs. 4, 5, 7 and 8. HF leaching of cassiterite targets inclusions and is unlikely to affect lattice-bound Pb and modify the isotope ratios as chemical abrasion does for zircon RMs.

Conclusions
The absolute dating of cassiterite using the U-Pb decay system offers the potential to link the hydrothermal processes responsible for Sn mineralisation to the regional-and localscale (deposit) magmatic-hydrothermal systems that may or may not be related to their genesis. Recent studies (e.g. Liu et al., 2007;Moscati and Neymark, 2019;Neymark et al., 2018;Yuan et al., 2011Yuan et al., , 2008Zhang et al., 2017;and others) have demonstrated the potential of cassiterite for U-Pb geochronology using microbeam methods (LA-ICP-MS) applied to the mineral from a wide range of deposits. The lack of materials that have characterised U-Pb compositions via total dissolution isotope dilution methods, and the difficulties in obtaining these, has led to the development of calibrations using inferred ages for ad hoc reference materials and impedes the verification of U-Pb datasets generated. We have demonstrated that useful amounts of cassiterite can be fully decomposed under closed-system conditions using readily obtainable and low-Pbc blank HBr acid over timescales and with an apparatus similar to those used in zircon ID-TIMS work. Increasing the surface area to volume ratio (e.g. using a pestle and mortar) is in fact an advantage when utilised with an HF-leaching step, as it not only expedites cassiterite decomposition, but will also expose Pbc-bearing inclusions that can be leached and rinsed away, along with any material abraded during crushing in a pestle and mortar. The notorious acid resistance of cassiterite works to our advantage as HF leaching leaves the lattice-bound U-Pb systematics intact. The methodology presented here indicates that Pb can be isolated using a simple modification of the AG-1x8 resin HCl-based anion exchange chromatography typically used for zircon, with no detectable penalties for ionisation by TIMS, and a further AG-1x8 HCl-and HNO 3 -based scheme is effective for the U elution.
The U-Pb ID-TIMS data presented for a range of materials between ∼ 150 and ∼ 1600 Ma demonstrate that cassiterite ID-TIMS U-Pb geochronology can potentially generate U-Pb lower intercept dates at ± < 0.1 % precision from a relatively low number of analyses. Using the classic example of the W-Sn greisen deposit at Cligga Head, UK, we demonstrate that the implementation of "internal isochrones" from sub-aliquots of powdered fragments can derive a U-Pb ID-TIMS cassiterite age interpretation consistent with an independent high-precision zircon CA-ID-TIMS U-Pb constraint on the age of cassiterite. These direct constraints show that the hydrothermal system was relatively short-lived, illustrating the potential of this method to define causative magmatic events. However, unknowns regarding the initial isotopic disequilibrium of cassiterite probably limit the true uncertainty on the age to ∼ 400 kyr.
Comparison of ID-TIMS and previously reported LA-ICP-MS U-Pb datasets for the three samples indicates that the latter are accurate at the ∼ 1 % (2σ ) level, especially when taking into account the ID-TIMS date that was ∼ 0.4 % younger than the inferred age for the SPG-IV cassiterite used to normalise matrix effects in the Neymark et al. (2018) study. This direct U / Pb determination can be used to refine LA-ICP-MS data that are normalised to this ad hoc reference material, further improving the underpinning of cassiterite U-Pb via LA-ICP-MS. Further total-digestion ID-TIMS U-Pb analyses of cassiterite will further improve the method, hopefully providing additional reference materials for calibration and verification.
The high-precision data presented here indicate that intraand inter-grain variations occur in the isotopic composition of Pbc present within the cassiterite. The nature of greisen Sn hydrothermal systems and their association with continentally derived sedimentary packages may be conducive to localised and variably radiogenic Pbc compositions. The potential for these variations in Pbc compositions places limitations on the interpretive power of datasets as a function of single data-point precision. A cautious approach to the age interpretation of lower-precision microbeam datasets, beyond the issues of analytical precision, is advised. Data availability. Data to reproduce all plots presented here are provided within the Supplement Excel workbook.
Author contributions. ST and JB designed the experiments that were carried out by JB with contributions from ST. ST interpreted the data and prepared the paper with contributions from JB.
Competing interests. The authors declare that they have no conflict of interest.